Y Chromosome FISH
Also known as: Y FISH, Y Chromosome FISH Panel« Back to test list
The Y chromosome is the smallest of the human chromosomes. It may not be possible to resolve details of a structural abnormality of the Y chromosome by conventional chromsome studies. Clarification of any structural alterations using FISH probes can provide diagnostic and prognostic information, for example, in men with azospermia.
The test report will define the structural rearrangements of the Y chromosome and indicate the potential clinical significance of these rearrangements.
The FISH panel contains probes for the centromere, long and short arms of the Y chromosome.
This test can be requested by any medical practitioner. The test is usually performed following identification of a Y chromosome abnormality with conventional chromosome analysis.
2-5 mL blood in lithium heparin. Specimens may be collected by the requesting practitioner or at any Sonic Healthcare pathology collection centre.
To help ensure the quality of the test, a genetic test should be done with a dedicated sample whenever possible i.e. a sample collected specifically for that test rather than a sample that is used for multiple tests.
We also recommend that the patient or another adult check the labelling of request forms and sample tubes.