Trisomy 8 FISH
Also known as: Tri(8) FISH« Back to test list
Trisomy of chromosome 8 is a frequent, non-specific finding in several myeloid neoplasms, including acute myeloid leukaemia (AML) and myelodysplastic syndrome (MDS). This cytogenetic abnormality has prognostic implications.
In patients with MDS, trisomy 8 is associated with an intermediate prognosis. In patients with AML, trisomy 8 can be associated with intermediate or poor prognosis, depending on other cytogenetic abnormalities.
This is an assay for non-heritable mutations. It does not raise issues of ethics or consent that are different from most other investigations ordered in the routine care of a patient.
Fluorescent in situ hybridisation (FISH) analysis, using probes to specific regions of chromosome 8.
This test is usually requested by a haematologist or oncologist.
0.5 mL bone marrow in transport media (or 10 mL blood in lithium heparin if blasts>10%).
To help ensure the quality of the test, a genetic test should be done with a dedicated sample whenever possible i.e. a sample collected specifically for that test rather than a sample that is used for multiple tests.
We also recommend that the patient or another adult check the labelling of request forms and sample tubes.