Also known as: p53 FISH, 17p Deletion FISH« Back to test list
TP53 is one of the genes most frequently mutated in human cancer. Deletions of the TP53 gene can be identified in some patients with chronic lymphocytic leukaemia (CLL), and this has prognostic implications.
Presence of a TP53 deletion is associated with a poorer prognosis in CLL.
This is an assay for non-heritable mutations. It does not raise issues of ethics or consent that are different from most other investigations ordered in the routine care of a patient.
Fluorescent in situ hybridisation (FISH) analysis, using probes specific to the TP53 gene.
This test is usually requested by a haematologist or oncologist.
0.5 mL bone marrow in transport media, or 5-10 mL blood in lithium heparin.
To help ensure the quality of the test, a genetic test should be done with a dedicated sample whenever possible i.e. a sample collected specifically for that test rather than a sample that is used for multiple tests.
We also recommend that the patient or another adult check the labelling of request forms and sample tubes.