Also known as: t(1;19) FISH« Back to test list
Deletions of 1p and 19q are associated with tumours with oligodendroglial components. Combined alterations have been observed in up to 70% of oligodendrogliomas and 50% of mixed oligoastrocytomas. The co-deletion is due to an unbalanced translocation – t(1;19)(q10;p10). This test has prognostic implications.
Demonstration of co-deletion of 1p and 19q in oligodendroglioma has been shown to be associated with a favourable response to therapy.
This is an assay for non-heritable mutations. It does not raise issues of ethics or consent that are different from most other investigations ordered in the routine care of a patient.
Fluorescent in situ hybridisation (FISH) analysis, using probes to enumerate the 1p and 19q deletion status.
This test is usually requested by an oncologist. EGFR amplification is usually requested concurrently.
Formalin fixed, paraffin-embedded tissue (FFPE) – 10 sections of 4 uM thickness, dried overnight at 37 degrees onto charged/coated slides.