Also known as: t(X;18) FISH« Back to test list
The t(X;18) translocation results in fusion of the SS18 gene on chromosome 18 with one of three related genes on the short arm of the X. The probe determines breakage of SS18. This test has diagnostic implications.
The rearrangement is specific for synovial sarcoma, and occurs in around 80% of these tumours.
This is an assay for non-heritable mutations. It does not raise issues of ethics or consent that are different from most other investigations ordered in the routine care of a patient.
Fluorescent in situ hybridisation (FISH) analysis, using probes to detect gene fusions involving the SS18 gene.
This test is usually requested by an oncologist.
Formalin fixed, paraffin-embedded tissue (FFPE) – 10 sections of 4 uM thickness, dried overnight at 37 degrees onto charged/coated slides.