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Also known as: PTEN Deletion FISH

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The Phosphate and Tensin homologue (PTEN) gene on 10q23 is mutated in a wide range of cancers. Allelic loss is one of the most frequent events in gliomas. This test has diagnostic implications.

Clinical Utility

PTEN deletion occurs in around 30% of glioblastomas. Establishing the presence of the deletion can be an aid to diagnosis.

This is an assay for non-heritable mutations. It does not raise issues of ethics or consent that are different from most other investigations ordered in the routine care of a patient.



Test Method

Fluorescent in situ hybridisation (FISH) analysis, using probes to enumerate the PTEN gene.

Test Ordering

This test is usually requested by an oncologist.

Formalin fixed, paraffin-embedded tissue (FFPE) – 10 sections of 4 uM thickness, dried overnight at 37 degrees onto charged/coated slides.


Pricing note:

The price varies according to the specific clinical conditions for a particular patient. Please contact Sonic Genetics on 1800 010 447 for more information.

Medicare Rebate

This test is not rebated by Medicare. The laboratory assumes that the patient or client has provided informed financial consent for the test.

Turnaround Time

2 working days.

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