Also known as: PTEN Deletion FISH« Back to test list
The Phosphate and Tensin homologue (PTEN) gene on 10q23 is mutated in a wide range of cancers. Allelic loss is one of the most frequent events in gliomas. This test has diagnostic implications.
PTEN deletion occurs in around 30% of glioblastomas. Establishing the presence of the deletion can be an aid to diagnosis.
This is an assay for non-heritable mutations. It does not raise issues of ethics or consent that are different from most other investigations ordered in the routine care of a patient.
Fluorescent in situ hybridisation (FISH) analysis, using probes to enumerate the PTEN gene.
This test is usually requested by an oncologist.
Formalin fixed, paraffin-embedded tissue (FFPE) – 10 sections of 4 uM thickness, dried overnight at 37 degrees onto charged/coated slides.