Non-Invasive Prenatal Test
Also known as: NIPT« Back to test list
Non-invasive prenatal testing (NIPT) is a test of a pregnant woman’s blood to determine the chance of a developing baby having a chromosome abnormality, such as trisomy 21, 18 or 13, an abnormality in the number of sex chromosomes, or a deletion of chromosome 22q11.2. While screening tests for some of these abnormalities have been available for a number of decades, they are not nearly as accurate as NIPT, which is so accurate that it has led to a rapid fall in the number of amniocenteses being performed across Australia.
Sonic Genetics provides the Harmony® Prenatal Test. You will find further information for doctors and patients about the test in our dedicated section here.
A normal result is usually reassuring regarding the chromosomes tested, but it must be interpreted in the light of other factors which influence the risk of the fetus being chromosomally abnormal. The test has a small risk of providing a false negative result.
A high probability result MUST be confirmed by invasive cytogenetic testing, for example, amniocentesis, as false positive results can occur.
Analysis of millions of fragments of DNA in the maternal plasma provides a measure of the relative abundance of DNA from each chromosome. The abnormal abundance or lack of a specific chromosome or part of a chromosome suggests that the fetus has a chromosome abnormality.
This test can be requested by any medical practitioner. Doctors are strongly advised to review the information in our dedicated Harmony Prenatal Test section or to contact the laboratory on 1800 010 447 for advice before offering this test to their patients.
2 x 8.5 mL blood collected into dedicated specialised tubes. Samples collected into the common specimen tubes cannot be tested.
We also recommend that the patient or another adult check the labelling of request forms and sample tubes.
Collections must be booked through special collection centres by calling 1800 010 447. There are limits on the days of the week when samples can be collected (to allow for prompt shipping to the laboratory). There is a specific request form for this test which must be used as it confirms that the patient has consented to the test. Information regarding the woman and her pregnancy is required for accurate interpretation of the result.
For further information on Non-Invasive Prenatal Testing though Sonic Genetics please click here.