Also known as: N-MYC FISH, 2p23 FISH« Back to test list
The N-MYC (MYCN) oncogene is overexpressed in a number of tumours, such as gliomas, lung and PNET. The test has prognostic implications.
N-MYC amplification is particularly useful in neuroblastomas, where it is an indicator of poor prognosis.
This is an assay for non-heritable mutations. It does not raise issues of ethics or consent that are different from most other investigations ordered in the routine care of a patient.
Fluorescent in situ hybridisation (FISH) analysis, using probes to enumerate the N-MYC gene.
This test is usually requested by an oncologist.
Formalin fixed, paraffin-embedded tissue (FFPE) – 10 sections of 4 uM thickness, dried overnight at 37 degrees onto charged/coated slides.