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Also known as: B27

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A specific variant of the human leukocyte antigen B27, HLA-B*27, is associated with a variety of inflammatory disorders.

Clinical Utility

The presence of this variant indicates that a person is at increased likelihood of having seronegative arthritis, ankylosing spondylitis, anterior uveitis, iritis, psoriatic arthritis, Reiter’s syndrome and Crohn’s disease. The absence of this variant places a person at decreased likelihood of having these disorders, and of having severe manifestations of these disorders.

This is a not a diagnostic test and the result does not prove or exclude a specific clinical diagnosis in an affected person.



Test Method

Analysis of the gene sequence of the HLA-B genes for the presence of this specific variant.

Test Ordering

This test can be requested by any medical practitioner.

5 mL blood in EDTA. Specimens may be collected by the requesting practitioner or at any Sonic Healthcare pathology collection centre.

To help ensure the quality of the test, a genetic test should be done with a dedicated sample whenever possible i.e. a sample collected specifically for that test rather than a sample that is used for multiple tests.

We also recommend that the patient or another adult check the labelling of request forms and sample tubes.



This test may have a rebate for all or part of the cost.

Medicare Rebate

This test has a Medicare rebate of $34.50, subject to the requirements of the Medicare descriptor being met. The MBS item number is 73320.

Turnaround Time

2 working days.