Sex Mismatch FISH
Also known as: Sex mismatch FISH, chimerism FISH« Back to test list
If a patient has a bone marrow transplant from a person of the opposite gender, it is possible to monitor to degree of engraftment of the donor cells by measuring the relative abundance of XX (female) and XY (male) cells in marrow or blood.
X and Y chromosome status is used to quantify donor/recipient cells in sex mismatch transplants, allowing assessment of engraftment.
Fluorescent in situ hybridisation (FISH) analysis, using probes to the centromeres of chromosomes X and Y.
This test is usually requested by a haematologist or oncologist.
0.5 mL bone marrow in transport media or 10 mL blood in lithium heparin if clinically appropriate.
To help ensure the quality of the test, a genetic test should be done with a dedicated sample whenever possible i.e. a sample collected specifically for that test rather than a sample that is used for multiple tests.
We also recommend that the patient or another adult check the labelling of request forms and sample tubes.