ALK FISH (lymphoma)
Also known as: ALK FISH, ALCL FISH (lymphoma)« Back to test list
Gene fusions involving the ALK gene and other gene partners can occur in large B-cell lymphomas and T-cell anaplastic large cell lymphomas. These fusions allow diagnosis of a specific subtype of lymphoma.
Presence of an ALK fusion gene helps to define specific lymphoma subtypes (ALK positive large B-cell lymphoma and ALK positive anaplastic large cell lymphoma) with specific clinical and prognostic features.
This is an assay for non-heritable mutations. It does not raise issues of ethics or consent that are different from most other investigations ordered in the routine care of a patient.
Fluorescent in situ hybridisation (FISH) analysis, using probes to identify fusion of ALK with a partner gene.
This test is usually requested by a haematologist or oncologist.
0.5 mL bone marrow in transport media, or 5-10 mL blood in lithium heparin.
To help ensure the quality of the test, a genetic test should be done with a dedicated sample whenever possible i.e. a sample collected specifically for that test rather than a sample that is used for multiple tests.
We also recommend that the patient or another adult check the labelling of request forms and sample tubes.