Also known as: 6q21 FISH« Back to test list
Deletions affecting the long arm of chromosome 6, including the 6q21 region, are common in mature B-cell lymphoid neoplasms, for example, plasma cell neoplasms, mantle cell lymphoma, and B-cell non-Hodgkin lymphoma, particularly lymphoplasmacytic lymphoma. These deletions can assist in subsequent monitoring of disease.
Presence of a 6q21 deletion is not prognostically significant, but can be a marker for quantitative population size estimation.
This is an assay for non-heritable mutations. It does not raise issues of ethics or consent that are different from most other investigations ordered in the routine care of a patient.
Fluorescent in situ hybridisation (FISH) analysis, using probes located at 6q21.
This test is usually requested by a haematologist or oncologist.
0.5 mL bone marrow in transport media, or 5-10 mL blood in lithium heparin.
To help ensure the quality of the test, a genetic test should be done with a dedicated sample whenever possible i.e. a sample collected specifically for that test rather than a sample that is used for multiple tests.
We also recommend that the patient or another adult check the labelling of request forms and sample tubes.