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Tissue FISH studies

Also known as: POC FISH

Test category:

Reproductive - Miscarriage

Use of test


Abnormalities of chromosome structure or number can cause miscarriage. Chromosome analysis can detect these abnormalities in the products of conception. These abnormalities can provide diagnostic information.

If the tissue has been placed in formalin, no analysis through tissue culture is possible, however FISH studies can be used to look for the common trisomies. In some cases, microarray studies may also be successful with these tissues.


Most chromosome abnormalities identified in the products of conception after a spontaneous miscarriage are de novo events that do not carry medical implications for future pregnancies. Chromosome studies of the parents are usually not indicated.

However, parental studies may sometimes be recommended by the laboratory because of specific findings.

Ethical considerations:

This is an assay for mutations which may be heritable or de novo. It may raise issues of ethics or consent that are different from most other investigations ordered in the routine care of a patient.


Fluorescent in situ hybridisation (FISH) analysis using probes for the common trisomies.

Requesting the test


This test can be requested by any medical practitioner.

Sample required:

The sample required is formalin-fixed, parrafin embedded tissue (FFPE).

Turnaround time:

10 business days.


Up to $255.

If more information is required, the requesting clinician can call our laboratory on (07) 3377 8573.


This test is not rebated by Medicare. The laboratory assumes that the patient or client has provided informed financial consent for the test.

Click here for our billing policy.