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Single cell FISH

Also known as: IVF FISH, PGD FISH, preimplantation FISH

Test category:

Reproductive - IVF

Use of test

Purpose:

Abnormalities of chromosome number can cause spontaneous miscarriage, or the birth of a baby with congenital malformations and developmental delay. This is a rapid test of the numbers of selected chromosomes in a single cell from an embryo prior to implantation. The identification of such abnormalities allows selective implantation of euploid embryos.

Utility:

An abnormal result provides a genetic diagnosis and the basis for medical decision-making. A normal result does not exclude a genetic or heritable disorder.

Ethical considerations:

This is an assay for mutations which may be heritable or de novo. It may raise issues of ethics or consent that are different from most other investigations ordered in the routine care of a patient.

Methodology:

Analysis of the number of selected chromosomes by fluorescent in situ hybridisation (FISH).

Requesting the test

Ordering:

This test is usually requested by an obstetrician.

Sample required:

This test can only be done by prior arrangement.

Special instructions:

Please contact us on 1800 010 447 to discuss sample requirements.

Turnaround time:

2 business days.

Price:

Up to $255.

If more information is required, the requesting clinician can call our laboratory on (07) 3377 8573.

Rebate:

This test is not rebated by Medicare. The laboratory assumes that the patient or client has provided informed financial consent for the test.