Back to test list

Sex mismatch FISH

Also known as: Chimerism FISH

Test category:

Oncology - Chimerism

Use of test

Purpose:

If a patient has a bone marrow transplant from a person of the opposite gender, it is possible to monitor the degree of engraftment of the donor cells by measuring the relative abundance of XX (female) and XY (male) cells in marrow or blood.

Utility:

X and Y Chromosome status is used to quantify donor/recipient cells in sex mismatch transplants, allowing assessment of engraftment.

Ethical considerations:

This assay does not raise issues of ethics or consent that are different from most other investigations ordered in the routine care of a patient.

Methodology:

Fluorescent in situ hybridisation (FISH) analysis, using probes to the centromeres of Chromosomes X and Y.

Requesting the test

Ordering:

This test is usually requested by a haematologist or oncologist.

Sample required:

0.5 mL bone marrow in transport media or 10 mL blood in lithium heparin if clinically appropriate.

To help ensure the quality of the test, a genetic test should be done with a dedicated sample whenever possible i.e. a sample collected specifically for that test rather than a sample that is used for multiple tests.

We recommend that the patient or another adult check the labelling of request forms and sample tubes.

Turnaround time:

2 business days.

Price:

Up to $255.

If more information is required, the requesting clinician can call our laboratory on (07) 3377 8573.

Rebate:

This test is not rebated by Medicare. The laboratory assumes that the patient or client has provided informed financial consent for the test.

Click here for our billing policy.