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Pharmacogenomic (PGx) screen

Also known as: Pharmaco profile, PGx, Sonic PGx panel, pharmacogenomics, Cytochrome P450

Test category:

Pharmacogenomic - Medication Guidance

Use of test


This test detects clinically important genetic variants that affect drug metabolism. These variants modify the rate at which certain drugs are activated or broken down. This information can be used to predict whether a drug or drug dose is likely to be effective and identify patients at risk of serious or intolerable side-effects. Therefore, this testing has a role in identifying patients who may benefit from modified dosing or avoiding a specific drug.


The laboratory report includes the genotype result and metaboliser status for all genes included in the panel, and implications regarding drug choice or dose. Panel-based testing is advantageous because it provides information relevant to both current medications and those that may be prescribed in future.

Additional factors, including illness, nutrition and concurrent medication, can contribute to patient metaboliser status at a given time and should therefore be considered when using the result from this test to determine drug dosage.

Ethical considerations:

This test has a role in identifying patients who may benefit from avoiding a specific drug or dose, but it provides little useful information for people (including relatives) who are not taking the medications of concern. Testing of relatives is generally not recommended.


Mass spectrometry-based targeted detection of single nucleotide variants and copy number variant detection by real-time PCR.

Requesting the test


This test can be requested by any medical practitioner.

Request form:

Download the Pharmacogenomic (PGx) request form.

Sample required:

4 mL blood in EDTA is preferred. Buccal swabs are available on request, please contact the laboratory if this method of collection is required.

Specimens may be collected by the requesting practitioner or at any Sonic Healthcare collection centre (see link below).

To help ensure the quality of the test, a genetic test should be done with a dedicated sample whenever possible i.e. a sample collected specifically for that test rather than a sample that is used for multiple tests.

We recommend that the patient or another adult check the labelling of request forms and sample tubes. 

>Link to Sonic Healthcare collection centres

Special instructions:

There is a specific request form available for this test. Please list current and proposed medications on the request form. Please highlight any medications that have caused problems in the past.

Turnaround time:

10 business days.




This test is not rebated by Medicare. The laboratory assumes that the patient or client has provided informed financial consent for the test.

Click here for our billing policy.