Back to test list


Test category:

Oncology - Lung cancer

Use of test


NTRK1, NTRK2, and NTRK3 are oncogenes. Fusions involving one of these genes are present in a small number of lung and other solid tumours. This test identifies these gene fusions.


The presence of NTRK fusions is a sign of poor prognosis in lung tumours. There are also emerging therapies targeting tumours with NTRK fusions.

Ethical considerations:

This is an assay for non-heritable mutations. It does not raise issues of ethics or consent that are different from most other investigations ordered in the routine care of a patient.


Fluorescent in situ hybridisation (FISH) analysis using probes located within NTRK1, NTRK2, NTRK3.

Requesting the test


This test is usually requested by an oncologist. Please use the specific request form.

Request form:

Download the solid tumour somatic mutation request form.

Sample required:

Formalin-fixed, paraffin embedded tissue (FFPE) - 15 sections of 4 uM thickness, dried overnight at 37°C onto charged/coated slides.

Special instructions:

Please stain the first section with H&E, and label each slide with patient and block identifiers. Label the unstained sections sequentially (slides 2-15). The request should be accompanied by the somatic mutation request form (above) and a copy of the original histopathology report.

Turnaround time:

5 business days.


Up to $255.

If more information is required, the requesting clinician can call our laboratory on (07) 3377 8573.


This test is not rebated by Medicare. The laboratory assumes that the patient or client has provided informed financial consent for the test.

Click here for our billing policy.