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NTRK1, NTRK2, NTRK3 FISH

Test category:

Oncology - Lung cancer

Use of test

Purpose:

NTRK1, NTRK2, and NTRK3 are oncogenes. Fusions involving one of these genes are present in a small number of lung and other solid tumours. This test identifies these gene fusions.

Utility:

The presence of NTRK fusions is a sign of poor prognosis in lung tumours. There are also emerging therapies targeting tumours with NTRK fusions.

Ethical considerations:

This is an assay for non-heritable mutations. It does not raise issues of ethics or consent that are different from most other investigations ordered in the routine care of a patient.

Methodology:

Fluorescent in situ hybridisation (FISH) analysis using probes located within NTRK1, NTRK2, NTRK3.

Requesting the test

Ordering:

This test is usually requested by an oncologist. Please use the specific request form.

Request form:

Download the somatic mutation request form.

Sample required:

Formalin-fixed, paraffin embedded tissue (FFPE) - 15 sections of 4 uM thickness, dried overnight at 37°C onto charged/coated slides.

Special instructions:

Please stain the first section with H&E, and label each slide with patient and block identifiers. Label the unstained sections sequentially (slides 2-15). The request should be accompanied by the somatic mutation request form (above) and a copy of the original histopathology report.

Turnaround time:

5 business days.

Price:

Up to $255.

If more information is required, the requesting clinician can call our laboratory on (07) 3377 8573.

Rebate:

This test is not rebated by Medicare. The laboratory assumes that the patient or client has provided informed financial consent for the test.