Myxoid liposarcoma FISH

Also known as: t(12;16) FISH, CHOP-FUS FISH, FUS-DDIT3 FISH

Test category:

Oncology - Sarcoma

Use of test

Purpose:

The FUS-DDIT3 gene fusion is characteristic of Myxoid round cell liposarcomas .

Utility:

This test has diagnostic implications.

Ethical considerations:

This is an assay for non-heritable mutations. It does not raise issues of ethics or consent that are different from most other investigations ordered in the routine care of a patient.

Methodology:

Fluorescent in situ hybridisation (FISH) analysis, using probes to detect gene fusions involving the FUS and DDIT3 genes.

Requesting the test

Ordering:

This test is usually requested by an oncologist.

Request form:

Download somatic mutation request form.

Sample required:

Formalin-fixed, paraffin embedded tissue (FFPE) - 15 sections of 4 uM thickness, dried overnight at 37°C onto charged/coated slides.

Special instructions:

Please stain the first section with H&E, and label each slide with patient and block identifiers. Label the unstained sections sequentially (slides 2-15). The request should be accompanied by the somatic mutation request form (above) and a copy of the original histopathology report.

Turnaround time:

5 business days.

Price:

Up to $410.

If more information is required, the requesting clinician can call our laboratory on (07) 3377 8573.

Rebate:

This test is not rebated by Medicare. The laboratory assumes that the patient or client has provided informed financial consent for the test.