Back to test list

IRF4/DUSP22 FISH

Test category:

Oncology - Lymphoma

Use of test

Purpose:

Translocations involving IRF4 have a high specificity for cutaneous anaplastic large cell lymphoma. This FISH test identifies rearrangements involving the locus.

Utility:

IRF4/DUSP22 rearrangement has been identified in up to 30% of ALK negative anaplastic large cell lymphomas. Positivity for the rearrangement is a positive prognostic sign.

Ethical considerations:

This is an assay for non-heritable mutations. It does not raise issues of ethics or consent that are different from most other investigations ordered in the routine care of a patient.

Methodology:

Fluorescent in situ hybridisation (FISH) analysis, using probes to identify rearrangement involving IRF4/DUSP22.

Requesting the test

Ordering:

This test is usually requested by a haematologist or oncologist.

Sample required:

0.5 mL bone marrow in transport media, or 5-10 mL blood in lithium heparin.

To help ensure the quality of the test, a genetic test should be done with a dedicated sample whenever possible i.e. a sample collected specifically for that test rather than a sample that is used for multiple tests.

We recommend that the patient or another adult check the labelling of request forms and sample tubes.

Turnaround time:

5 business days.

Price:

Up to $255.

If more information is required, the requesting clinician can call our laboratory on (07) 3377 8573.

Rebate:

This test is not rebated by Medicare. The laboratory assumes that the patient or client has provided informed financial consent for the test.