Use of test
In lymphomas which lack an expected IGH translocation, the variants IGK and IGL may be involved.
This testing can allow diagnosis in cases of variant Burkitt lymphoma, for example.
This is an assay for non-heritable mutations. It does not raise issues of ethics or consent that are different from most other investigations ordered in the routine care of a patient.
Fluorescent in situ hybridisation (FISH) analysis, using probes to identify fusions involving IGK and IGL.
Requesting the test
This test is usually requested by a haematologist or oncologist.
0.5 mL bone marrow in transport media, or 5-10 mL blood in lithium heparin.
To help ensure the quality of the test, a genetic test should be done with a dedicated sample whenever possible i.e. a sample collected specifically for that test rather than a sample that is used for multiple tests.
We recommend that the patient or another adult check the labelling of request forms and sample tubes.
Up to 4 weeks.
Up to $255.
The laboratory assumes that the requestor has obtained financial consent from the patient for this test.
There is no Medicare rebate for this test. If more information is required, the requesting clinician can call our laboratory on (07) 3377 8573.