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Also known as: t(11;14) FISH, Mantle cell lymphoma (MCL) FISH

Test category:

Oncology - Lymphoma

Use of test


Gene fusions involving the IGH gene at 14q32 and CCND1 at 11q13 are seen most frequently in mantle cell lymphoma, but also in other B-cell disorders and multiple myeloma. The identification of such fusions can assist in diagnosis and classification of disease.


Presence of an IGH-CCND1 gene fusion can be useful in diagnosing mantle cell lymphoma.

Ethical considerations:

This is an assay for non-heritable mutations. It does not raise issues of ethics or consent that are different from most other investigations ordered in the routine care of a patient.


Fluorescent in situ hybridisation (FISH) analysis, using probes to identify fusion of IGH with CCND1, due to a t(11;14)(q13;q32) translocation.

Requesting the test


This test is usually requested by a haematologist or oncologist.

Sample required:

0.5 mL bone marrow in transport media, or formalin-fixed, paraffin embedded tissue.

To help ensure the quality of the test, a genetic test should be done with a dedicated sample whenever possible i.e. a sample collected specifically for that test rather than a sample that is used for multiple tests.

We recommend that the patient or another adult check the labelling of request forms and sample tubes.

Turnaround time:

2 business days.


Up to $255.

If more information is required, the requesting clinician can call our laboratory on (07) 3377 8573.


This test is not rebated by Medicare. The laboratory assumes that the patient or client has provided informed financial consent for the test.

Click here for our billing policy.