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IGH/CCND1 FISH

Also known as: t(11;14) FISH, Mantle cell lymphoma (MCL) FISH

Test category:

Oncology - Lymphoma

Use of test

Purpose:

Gene fusions involving the IGH gene at 14q32 and CCND1 at 11q13 are seen most frequently in mantle cell lymphoma, but also in other B-cell disorders and multiple myeloma. The identification of such fusions can assist in diagnosis and classification of disease.

Utility:

Presence of an IGH-CCND1 gene fusion can be useful in diagnosing mantle cell lymphoma.

Ethical considerations:

This is an assay for non-heritable mutations. It does not raise issues of ethics or consent that are different from most other investigations ordered in the routine care of a patient.

Methodology:

Fluorescent in situ hybridisation (FISH) analysis, using probes to identify fusion of IGH with CCND1, due to a t(11;14)(q13;q32) translocation.

Requesting the test

Ordering:

This test is usually requested by a haematologist or oncologist.

Sample required:

0.5 mL bone marrow in transport media, or formalin-fixed, paraffin embedded tissue.

To help ensure the quality of the test, a genetic test should be done with a dedicated sample whenever possible i.e. a sample collected specifically for that test rather than a sample that is used for multiple tests.

We recommend that the patient or another adult check the labelling of request forms and sample tubes.

Turnaround time:

2 business days.

Price:

Up to $255.

If more information is required, the requesting clinician can call our laboratory on (07) 3377 8573.

Rebate:

This test is not rebated by Medicare. The laboratory assumes that the patient or client has provided informed financial consent for the test.

Click here for our billing policy.