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HLA-B5801

Also known as: B5801

Test category:

Immunology - Hypersensitivity ; Pharmacogenomic - Hypersensitivity

Use of test

Purpose:

A specific variant of the human leukocyte antigen B58, HLA-B*58:01, is associated with severe cutaneous adverse reactions (SCAR) to the medication, allopurinol.

Utility:

The presence of this variant indicates that a person is at increased risk of a hypersensitivity reaction to allopurinol.

Ethical considerations:

This test has a role in identifying patients who may benefit from avoiding a specific drug or dose, but it provides little useful information for people (including relatives) who are not taking the medications of concern. Testing of relatives is generally not recommended.

Methodology:

Analysis of the gene sequence of the HLA-B genes for the presence of this specific variant.

Requesting the test

Ordering:

This test can be requested by any medical practitioner.

Sample required:

4 mL blood in EDTA. Specimens may be collected by the requesting practitioner or at any Sonic Healthcare collection centre (see link below).

To help ensure the quality of the test, a genetic test should be done with a dedicated sample whenever possible i.e. a sample collected specifically for that test rather than a sample that is used for multiple tests.

We recommend that the patient or another adult check the labelling of request forms and sample tubes. 

>Link to Sonic Healthcare collection centres

Turnaround time:

2 business days.

Price:

$75.

Rebate:

This test is not rebated by Medicare. The laboratory assumes that the patient or client has provided informed financial consent for the test.

Click here for our billing policy.