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ALK FISH (lymphoma)

Also known as: ALCL FISH (lymphoma)

Test category:

Oncology - Lymphoma

Use of test


Gene fusions involving the ALK gene and other gene partners can occur in large B-cell lymphomas and T-cell anaplastic large cell lymphomas. These fusions allow diagnosis of a specific subtype of lymphoma.


Presence of an ALK fusion gene helps to define specific lymphoma subtypes (ALK positive large B-cell lymphoma and ALK positive anaplastic large cell lymphoma) with specific clinical and prognostic features.

Ethical considerations:

This is an assay for non-heritable mutations. It does not raise issues of ethics or consent that are different from most other investigations ordered in the routine care of a patient.


Fluorescent in situ hybridisation (FISH) analysis, using probes to identify fusion of ALK with a partner gene. The breakpoints involved in these fusions can be variable, and in some cases certain variants will not be detected by the probe.

Requesting the test


This test is usually requested by a haematologist or oncologist.

Sample required:

0.5 mL bone marrow in transport media, or formalin-fixed paraffin embedded tissue (FFPE).

To help ensure the quality of the test, a genetic test should be done with a dedicated sample whenever possible i.e. a sample collected specifically for that test rather than a sample that is used for multiple tests.

We recommend that the patient or another adult check the labelling of request forms and sample tubes.

Turnaround time:

5 business days.


Up to $255.

If more information is required, the requesting clinician can call our laboratory on (07) 3377 8573.


This test is not rebated by Medicare. The laboratory assumes that the patient or client has provided informed financial consent for the test.

Click here for our billing policy.