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6q21 deletion FISH

Test category:

Oncology - Lymphoma

Use of test


Deletions affecting the long arm of Chromosome 6, including the 6q21 region, are common in mature B-cell lymphoid neoplasms, for example, plasma cell neoplasms, mantle cell lymphoma, and B-cell non-Hodgkin lymphoma, particularly lymphoplasmacytic lymphoma. These deletions can assist in subsequent monitoring of disease.


Presence of a 6q21 deletion is not prognostically significant, but can be a marker for presence of a monoclonal population, or for quantitative population size estimation.

Ethical considerations:

This is an assay for non-heritable mutations. It does not raise issues of ethics or consent that are different from most other investigations ordered in the routine care of a patient.


Fluorescent in situ hybridisation (FISH) analysis, using probes located at 6q21. This interphase FISH test has a cut off at 5%. A low level of positive cells may be due to overlap of the two signals. Studies of normal controls indicate that this level is less than 5%. Small abnormal populations may therefore not be detectable.

Requesting the test


This test is usually requested by a haematologist or oncologist.

Sample required:

0.5 mL bone marrow in transport media, or 5-10 mL blood in lithium heparin.

To help ensure the quality of the test, a genetic test should be done with a dedicated sample whenever possible i.e. a sample collected specifically for that test rather than a sample that is used for multiple tests.

We recommend that the patient or another adult check the labelling of request forms and sample tubes.

Turnaround time:

5 business days.


Up to $255.

If more information is required, the requesting clinician can call our laboratory on (07) 3377 8573.


This test is not rebated by Medicare. The laboratory assumes that the patient or client has provided informed financial consent for the test.

Click here for our billing policy.