Making medicines personal
Pharmacogenomic (PGx) testing allows you to personalise your patient’s medication according to their genetic variation. This has been shown to improve clinical outcomes by enhancing therapeutic efficacy and improving clinical safety.
The Sonic PGx panel is a 10-gene pharmacogenomic test that provides guidance on medication and dose across common therapeutic areas, including cardiology, gastroenterology, pain management, psychiatry and addiction medicine.
While the Sonic PGx panel is available to all Australians, it is most useful for patients:
- Experiencing unwelcome side effects or not responding to medication; or
- About to commence medications where PGx has been shown to influence clinical outcomes.
The genes tested on the Sonic PGx panel are:
CYP2D6, CYP2C19, CYP1A2, CYP3A4, CYP3A5, CYP2C9, VKORC1, ABCB1, OPRM1 and SLCO1B1.
Sonic PGx panel reporting
Clinically relevant and ready-to-use
Sonic Genetics, in collaboration with an internationally recognised interpretive service, Translational Software, provides an evidence-based and clinically applicable report, incorporating recommendations from expert pharmacogenomic groups and associations in an easy-to-read format.
The report includes:
- Prescribing recommendations for current or proposed medications
- Genotypes, predicted metaboliser/activity status and potential drug-gene interactions
- The evidence level supporting the PGx guidance
PGx guidance is intended as additional clinical information doctors can utilise to explain or pre-empt potential medication related problems and inform prescribing decisions.
Single gene tests available
Specific single gene tests are independent of the Sonic PGx panel and include:
- HLA Typing
These can be requested using your local pathology request form and some may be legible for a Medicare rebate.
Click here for more information and pricing.
Arranging a Sonic PGx panel
- Complete a Pharmacogenomic (PGx) panel request form or request the ‘Sonic PGx panel’ using your local pathology request form. Maximise the value from the PGx test by providing information regarding your patient’s clinical state and current or proposed medications.
- Send your patient to any Sonic Healthcare pathology collection centre for a blood test.
- Sonic PGx panel reports are delivered via Sonic Dx or courier, usually within 10 business days following receipt of the sample in our laboratory.
Medicare does not cover the cost of the Sonic PGx panel and your patient will receive an invoice. Please refer to test details for current pricing.
- Pharmacogenomics (PGx) information for doctors
- Sonic PGx panel example report
- Sonic PGx - guide to understand the report
- Sonic PGx - how to securely email a report via Sonic Dx
- Pharmacogenomics (PGx) patient information
- Pharmacogenomics (PGx) test list
- Pharmacogenomics (PGx) panel request form
- Pharmacogenomics (PGx) in cardiology - information for doctors
- Pharmacogenomics (PGx) in mental health - information for doctors
- Pharmacogenomics (PGx) in mental health - information for GPs
- Pharmacogenomics (PGx) in psychotropic therapy
- Pharmacogenomics (PGx) personalise the prescribing of codeine
- Pharmacogenomics (PGx) pharmacogenomics and major depressive disorder
- Pharmacogenomics (PGx) pharmacogenomics of agomelatine
- Pharmacogenomics (PGx) to predict 5-FU/capecitabine toxicity
- Pharmacogenomics (PGx) to avoid allopurinol hypersensitivity
- Pharmacogenomics (PGx) to avoid phenytoin hypersensitivity and toxicity
- Pharmacogenomics (PGx) to predict UGT1A1/irinotecan toxicity
- Pharmacogenomics (PGx) to inform tamoxifen prescribing
- Sonic PGx panel gene monographs
Audio & Video
Pharmacogenomics to avoid severe drug reactions in psychiatry: when to test and why (52 minutes)
What is pharmacogenetics? (32 minutes)
Drugs & Genes: Pharmacogenetics and Pathology (26 minutes)
For training videos on this subject and other genetic tests, please visit our Doctor Education website.