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Oligodendroglioma FISH

Also known as: t(1;19) FISH

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Purpose

Deletions of 1p and 19q are associated with tumours with oligodendroglial components. Combined alterations have been observed in up to 70% of oligodendrogliomas and 50% of mixed oligoastrocytomas. The co-deletion is due to an unbalanced translocation – t(1;19)(q10;p10). This test has prognostic implications.

Clinical Utility

Demonstration of co-deletion of 1p and 19q in oligodendroglioma has been shown to be associated with a favourable response to therapy.

This is an assay for non-heritable mutations. It does not raise issues of ethics or consent that are different from most other investigations ordered in the routine care of a patient.

Genes

Not specified

Test Method

Fluorescent in situ hybridisation (FISH) analysis, using probes to enumerate the 1p and 19q deletion status.

Test Ordering

This test is usually requested by an oncologist. EGFR amplification is usually requested concurrently.

Formalin fixed, paraffin-embedded tissue (FFPE) – 10 sections of 4 uM thickness, dried overnight at 37 degrees onto charged/coated slides.

Price

$410

Medicare Rebate

This test is not rebated by Medicare. The laboratory assumes that the patient or client has provided informed financial consent for the test.

Turnaround Time

2 working days.

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