Our Tests

Non-Invasive Prenatal Test

Also known as: NIPT

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Purpose

Non-invasive prenatal testing (NIPT) is a test of a pregnant woman’s blood to determine the chance of a developing baby having a serious chromosome abnormality. Screening tests for these abnormalities have been available for a number of decades, but the older screening tests are not nearly as accurate as NIPT. NIPT is so accurate that it has led to a rapid fall in the number of amniocenteses being performed across Australia.

Sonic Genetics provides the Harmony™ Prenatal Test. You will find further information for doctors and patients about the test in our dedicated section here.

Clinical Utility

A normal result is usually reassuring regarding the chromosomes tested, but it must be interpreted in the light of other factors which influence the risk of the fetus being chromosomally abnormal. The test has a small risk of providing a false negative result.

An abnormal result MUST be confirmed by invasive cytogenetic testing, for example, amniocentesis.

Genes

Not specified

Test Method

Analysis of millions of fragments of DNA in the maternal plasma provides a measure of the relative abundance of DNA from each chromosome. The abnormal abundance of a specific chromosome suggests that the fetus has a chromosome abnormality.

Test Ordering

This test can be requested by any medical practitioner. Doctors are strongly advised to review the information in our dedicated Harmony Prenatal Test section or to contact the laboratory on 1800 010 447 for advice before offering this test to their patients.

2 x 8.5 ml blood collected into specialised tubes. Samples collected into the common specimen tubes cannot be tested.

To help ensure the quality of the test, a genetic test should be done with a dedicated sample whenever possible i.e. a sample collected specifically for that test rather than a sample that is used for multiple tests.

We also recommend that the patient or another adult check the labelling of request forms and sample tubes.

Special Instructions

Collections must be booked through special collection centres by calling 1800 010 447. There are limits on the days of the week when samples can be collected (to allow for prompt shipping to the laboratory). There is a specific request form for this test which must be used. Information regarding the woman and her pregnancy are required for accurate interpretation of the result.

For further information on Non-Invasive Prenatal Testing though Sonic Genetics please click here.