Our Tests

KMT2A FISH

Also known as: MLL FISH

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Purpose

MLL (also known as KMT2A) is located at 11q23. It can undergo gene fusion with a variety of partner genes in several types of acute leukaemia. This fusion carriers prognostic implications.

Clinical Utility

Presence of an MLL fusion gene is typically associated with a poor prognosis.

This is an assay for non-heritable mutations. It does not raise issues of ethics or consent that are different from most other investigations ordered in the routine care of a patient.

Genes

KMT2A

Test Method

Fluorescent in situ hybridisation (FISH) analysis, using probes to identify fusion of MLL with various partner genes.

Test Ordering

This test is usually requested by a haematologist or oncologist.

0.5 mL bone marrow in transport media, or 10 mL blood in lithium heparin.

To help ensure the quality of the test, a genetic test should be done with a dedicated sample whenever possible i.e. a sample collected specifically for that test rather than a sample that is used for multiple tests.

We also recommend that the patient or another adult check the labelling of request forms and sample tubes.

Price

$230.95

This test may have a rebate for all or part of the cost.

Medicare Rebate

This test has a Medicare rebate of $196.35, subject to the requirements of the Medicare descriptor being met. The MBS item number is 73314.

Turnaround Time

2 working days.