Our Tests

FUS/DDIT3 FISH

Also known as: t(12;16) FISH

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Purpose

The t(12;16) translocation results in fusion of the FUS and DDIT3 genes. This test has diagnostic implications.

Clinical Utility

FUS-DDIT3 fusion or variants having FUS rearrangement with other partners are seen in about 90% of myxoid liposarcomas, and can be useful as a diagnostic aid.

This is an assay for non-heritable mutations. It does not raise issues of ethics or consent that are different from most other investigations ordered in the routine care of a patient.

Test Method

Fluorescent in situ hybridisation (FISH) analysis using probes to detect the FUS-DDIT3 fusion gene. The probes used are individual breakapart probes for FUS and DDIT3, so variants are detected.

Test Ordering

This test is usually requested by an oncologist.

Formalin fixed, paraffin-embedded tissue (FFPE) – 10 sections of 4 uM thickness, dried overnight at 37 degrees onto charged/coated slides.

Price

$355 - $410

The price varies according to the specific clinical conditions for a particular patient. Please contact Sonic Genetics on 1800 010 447 for more information.

Medicare Rebate

This test is not rebated by Medicare. The laboratory assumes that the patient or client has provided informed financial consent for the test.

Turnaround Time

2 working days.

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