Our Tests

Chronic Lymphocytic Leuk FISH

Also known as: Chronic Lymphocytic Leukaemia FISH Panel, CLL FISH

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Purpose

Changes in chromosome structure and number in leukaemic cells can provide important prognostic and therapeutic information in patients with chronic lymphocytic leukaemia (CLL). A panel of probes is used to look for the most frequent abnormalities, 13q deletion, trisomy 12, ATM deletion and p53 deletion.

Clinical Utility

The laboratory report defines the changes in the patient’s malignant cells and relates these changes to the current management recommendations.

This is an assay for non-heritable mutations. It does not raise issues of ethics or consent that are different from most other investigations ordered in the routine care of a patient.

Test Method

Fluorescent in situ hybridisation (FISH) analysis, using probes specific to the relevant targets.

Test Ordering

This test is usually requested by a haematologist or oncologist.

0.5 mL bone marrow in transport media or 10 mL blood in lithium heparin if clinically appropriate.

To help ensure the quality of the test, a genetic test should be done with a dedicated sample whenever possible i.e. a sample collected specifically for that test rather than a sample that is used for multiple tests.

We also recommend that the patient or another adult check the labelling of request forms and sample tubes.

Price

$255

Medicare Rebate

This test is not rebated by Medicare. The laboratory assumes that the patient or client has provided informed financial consent for the test.

Turnaround Time

2 working days.

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