Our Tests

Sex Mismatch FISH

Also known as: Sex mismatch FISH, chimerism FISH

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Purpose

If a patient has a bone marrow transplant from a person of the opposite gender, it is possible to monitor to degree of engraftment of the donor cells by measuring the relative abundance of XX (female) and XY (male) cells in marrow or blood.

Clinical Utility

X and Y chromosome status is used to quantify donor/recipient cells in sex mismatch transplants, allowing assessment of engraftment.

Genes

Not specified

Test Method

Fluorescent in situ hybridisation (FISH) analysis, using probes to the centromeres of chromosomes X and Y.

Test Ordering

This test is usually requested by a haematologist or oncologist.

0.5 mL bone marrow in transport media or 10 mL blood in lithium heparin if clinically appropriate.

To help ensure the quality of the test, a genetic test should be done with a dedicated sample whenever possible i.e. a sample collected specifically for that test rather than a sample that is used for multiple tests.

We also recommend that the patient or another adult check the labelling of request forms and sample tubes.

Price

$205 - $255

The price varies according to the specific clinical conditions for a particular patient. Please contact Sonic Genetics on 1800 010 447 for more information.

Medicare Rebate

This test is not rebated by Medicare. The laboratory assumes that the patient or client has provided informed financial consent for the test.

Turnaround Time

2 working days.