Our Tests

ALK FISH (lymphoma)

Also known as: ALK FISH, ALCL FISH (lymphoma)

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Purpose

Gene fusions involving the ALK gene and other gene partners can occur in large B-cell lymphomas and T-cell anaplastic large cell lymphomas. These fusions allow diagnosis of a specific subtype of lymphoma.

Clinical Utility

Presence of an ALK fusion gene helps to define specific lymphoma subtypes (ALK positive large B-cell lymphoma and ALK positive anaplastic large cell lymphoma) with specific clinical and prognostic features.

This is an assay for non-heritable mutations. It does not raise issues of ethics or consent that are different from most other investigations ordered in the routine care of a patient.

Genes

ALK

Test Method

Fluorescent in situ hybridisation (FISH) analysis, using probes to identify fusion of ALK with a partner gene.

Test Ordering

This test is usually requested by a haematologist or oncologist.

0.5 mL bone marrow in transport media, or 5-10 mL blood in lithium heparin.

To help ensure the quality of the test, a genetic test should be done with a dedicated sample whenever possible i.e. a sample collected specifically for that test rather than a sample that is used for multiple tests.

We also recommend that the patient or another adult check the labelling of request forms and sample tubes.

Price

Pricing note:

The price varies according to the specific clinical conditions for a particular patient. Please contact Sonic Genetics on 1800 010 447 for more information.

Medicare Rebate

This test is not rebated by Medicare. The laboratory assumes that the patient or client has provided informed financial consent for the test.

Turnaround Time

2 working days.

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